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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-05-02 to 2019-05-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
March 23, 2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
August 24, 2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
August, 1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
OGYÉI- National Institute of Pharmacy and Nutrition (21.04.2016)
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
Test Item was used in its initial form.
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
25 °C
Vapour pressure:
0 Pa

The vapour pressure was measured in the temperature range of 110 to 160 °C. For the evaluation the vapour pressure values in the range of 135 to 160 °C were used. The measured vapour pressure values together with the measured temperatures and the regression data of the vapour pressure curve can be seen in Tables 1 and 2, respectively.

Table 1: Results of the Effusion method

 Temperature, °C Δm/Δt, mg/min  Vapour pressure, Pa
 135.0  5.0078 x 10-5  7.3680 x 10-3
 140.0  5.2091 x 10-5  7.7109 x 10-3
 145.0  6.8733 x 10-5  1.0236 x 10-2
 150.0  1.0300 x 10-4  1.5430 x 10-2
 155.0  1.6687 x 10-4  2.5146 x 10-2
 160.0  3.1379 x 10-4  4.7561 x 10-2

Table 2: Regression data of the vapour pressure curve - Regression output

 Intercept  Slope  R. Squared
 11.9650  -5799.7396  0.9270

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C:

Vapour pressure of test item at 20 °C: 1.516 x 10-8 Pa

Vapour pressure of test item at 25 °C: 3.255 x 10-8 Pa

Conclusions:
Vapour pressure of test item at 20 °C: 1.516 x 10-8 Pa
Vapour pressure of test item at 25 °C: 3.255 x 10-8 Pa
Executive summary:

Vapour pressure of the test item was determined using Vapor Pressure Analyzer (Knudsen Effusion Method) following internationally accepted guidelines (OECD 104, EU Method A.4, OPPTS 830.7950) and under GLP compliance.

The vapour pressure was measured in the temperature range of 110 to 160 °C. For the evaluation the vapour pressure values in the range of 135 to 160 °C were used.

The following results were obtained:

Vapour pressure of test item at 20 °C: 1.516 x 10-8 Pa

Vapour pressure of test item at 25 °C: 3.255 x 10-8 Pa

Description of key information

Vapour pressure of the test item was determined using Vapor Pressure Analyzer (Knudsen Effusion Method) following internationally accepted guidelines (OECD 104, EU Method A.4, OPPTS 830.7950) and under GLP compliance.

The vapour pressure was measured in the temperature range of 110 to 160 °C. For the evaluation the vapour pressure values in the range of 135 to 160 °C were used.

The following result were obtained:

Vapour pressure of test item at 20 °C: 1.516 x 10-8 Pa

Vapour pressure of test item at 25 °C: 3.255 x 10-8 Pa

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information