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EC number: 257-048-2 | CAS number: 51200-87-4
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-21 October 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- (EC) No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- dynamic method
Test material
- Reference substance name:
- 4,4-dimethyloxazolidine
- EC Number:
- 257-048-2
- EC Name:
- 4,4-dimethyloxazolidine
- Cas Number:
- 51200-87-4
- Molecular formula:
- C5H11NO
- IUPAC Name:
- 4,4-dimethyl-1,3-oxazolidine
- Reference substance name:
- 2,3-dimethyl-1,3-oxazinane
- Cas Number:
- 31951-99-2
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 2,3-dimethyl-1,3-oxazinane
- Reference substance name:
- 3,5,5-trimethylmorpholin-2-one
- Cas Number:
- 57765-62-5
- Molecular formula:
- C7H13NO2
- IUPAC Name:
- 3,5,5-trimethylmorpholin-2-one
- Test material form:
- liquid
- Details on test material:
- Lot no. MA20190405
Test item storage 2–8 °C, protected from light
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Batch No.: MA20190405
Storage: Refrigerator (approx. 2-8°C)
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 50 °C
- Vapour pressure:
- 45.8 hPa
- Remarks on result:
- other: calculated by interpolation and extrapolation of the measured vapour pressure curve
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 10.8 hPa
- Remarks on result:
- other: calculated by interpolation and extrapolation of the measured vapour pressure curve
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 7.9 hPa
- Remarks on result:
- other: calculated by interpolation and extrapolation of the measured vapour pressure curve
Any other information on results incl. tables
Dynamic method:
The vapour pressure was measured in the temperature range of 46 °C to 68 °C. The results of the dynamic method are given in the table below:
No. |
Temperature / °C |
Vapour pressure / hPa |
Remark |
1 |
46.0 |
35.6 |
measured up |
2 |
52.1 |
51.5 |
measured up |
3 |
55.9 |
64.6 |
measured up |
4 |
61.0 |
79.4 |
measured up |
5 |
64.3 |
94.8 |
measured up |
6 |
67.5 |
108.9 |
measured up |
7 |
65.8 |
101.4 |
measured down |
8 |
62.5 |
87.3 |
measured down |
9 |
55.2 |
62.2 |
measured down |
From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation:
log10(p) = A + B/(C+t)
can be derived by regression (Microsoft Excel) of the data points to
A = 11.1284
B = -2413.09
C = 273.15.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the test item 4,4-dimethyloxazolidine (CAS no. 51200-87-4) was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20 °C, 25 °C and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006):
20°C: 7.9 hPa;
25°C: 10.8 hPa;
50°C: 45.8 hPa. - Executive summary:
The vapour pressure of the test item 4,4-dimethyloxazolidine (CAS no. 51200-87-4) was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20 °C, 25 °C and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006):
20°C: 7.9 hPa
25°C: 10.8 hPa
50°C: 45.8 hPa
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