4,4-dimethyloxazolidine

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17-18 September 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Version / remarks:

1996

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

EC No. 440/2008

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

4,4-dimethyloxazolidine

EC Number:

257-048-2

EC Name:

4,4-dimethyloxazolidine

Cas Number:

51200-87-4

Molecular formula:

C5H11NO

IUPAC Name:

4,4-dimethyl-1,3-oxazolidine

impurity 1

Reference substance name:

2,3-dimethyl-1,3-oxazinane

Cas Number:

31951-99-2

Molecular formula:

C6H13NO

IUPAC Name:

2,3-dimethyl-1,3-oxazinane

impurity 2

Reference substance name:

3,5,5-trimethylmorpholin-2-one

Cas Number:

57765-62-5

Molecular formula:

C7H13NO2

IUPAC Name:

3,5,5-trimethylmorpholin-2-one

Test material form:

liquid

Details on test material:

Lot no. MA20190405
Test item storage 2–8 °C, protected from light

Specific details on test material used for the study:

Batch No.: MA20190405
Storage: Refrigerator (approx. 2-8°C)

Results and discussion

Boiling point

Key result

Boiling pt.:

>= 129 - <= 131 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Any other information on results incl. tables

The results of the DSC-measurements are given in the table below:

Measurement No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
PN20209	9.31	131.10	40 – 170 (endo)	9.31	1023.0
PN20210	9.70	129.82	40 – 160 (endo)	9.70	1023.0

During the heating phase a distinct endothermic effect was observed in the temperature range of 40-170°C, which can be assigned to the boiling of the test item.

For the correction of the boiling temperature to standard pressure the test item was assigned to chemical group 3 (e.g. amines). A correction value f = 5.05 was used for the temperature of 130 °C.

The lowest measured onset temperature is corrected to standard pressure to be 129.49 °C and the highest onset temperature to be 130.77 °C. As the corrected onset temperatures in both tests deviate by more than 0.5 K from their mean value of 130.13 °C, the test item has a boiling range of 129 – 131 °C.

Applicant's summary and conclusion

Conclusions:

The test item 4,4-dimethyloxazolidine (CAS no. 51200-87-4) has a boiling range of
129 – 131 °C at standard pressure (1013 hPa) as determined by Differential Scanning Calorimetry according to Regulation (EC) No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).

Executive summary:

The test item 4,4-dimethyloxazolidine (CAS no. 51200-87-4) has a boiling range of
129 – 131 °C at standard pressure (1013 hPa) as determined by Differential Scanning Calorimetry according to Regulation (EC) No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).