Registration Dossier
Registration Dossier
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EC number: 832-253-5 | CAS number: 12165-18-3
Endpoint summary
Administrative data
Description of key information
There is no experimental data available on skin sensitisation for the substance dipraseodymium dizirconium heptaoxide. However, using a weight of evidence approach including experimental data available for its constituents praseodymium(III,IV) oxide and zirconium dioxide (in the latter case, a zirconium dioxide test item was used in which a small amount of yttrium oxide was incorporated in the crystal lattice), it can be concluded that the substance is not expected to be a skin sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
1. Information on praseodymium(III,IV) oxide
In a study (Henzell, 2012; Klimisch 1) conducted to test the skin sensitisation properties of praseodymium(III,IV) oxide following OECD guideline 429 (LLNA), the results for all concentrations of the test material were negative. The positive control material yielded the expected result. Therefore, praseodymium(III,IV) oxide was considered to be a non-sensitiser under the conditions of this study in accordance with the CLP criteria.
2. Information on zirconium dioxide
Since no skin reaction was acknowledged in the elicited region of either the test agent group or the control group in the OECD 406 study (GPMT) performed by the Japanese Chemical Inspection and Testing Institute (1999; Klimisch 2 (non-GLP)), it was concluded that the test substance yttrium zirconium oxide (i.e. zirconium dioxide with a small amount of yttrium oxide incorporated into its crystal lattice) does not have any skin sensitising potential under the conditions of this test. On the other hand, it was confirmed that 2,4-dinitrochlorobenzene, the positive control agent, has an extreme skin sensitising potential. Since the result for the yttrium zirconium oxide test item was negative, it can be concluded that zirconium dioxide is also not a sensitiser.
3. Conclusion for the substance dipraseodymium dizirconium heptaoxide
Based on the negative results obtained for praseodymium(III,IV) oxide and zirconium dioxide (with a small amount of yttrium oxide incorporated into its crystal lattice) in skin sensitisation studies, it is safe to conclude that the substance dipraseodymium dizirconium heptaoxide does not need to be classified for skin sensitisation either.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance does not need to be classified as skin sensitiser. This conclusion is based on the negative results of experiments performed with praseodymium(III,IV) oxide and zirconium dioxide (with a small amount of yttrium oxide incorporated into its crystal lattice).
No information is available on respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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