Registration Dossier
Registration Dossier
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EC number: 252-743-7 | CAS number: 35835-94-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 2017 until April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Transformation products:
- no
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Less than 10% hydrolysis after 5 days at 50 °C,
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- >= 1 yr
- Type:
- not specified
- Remarks on result:
- other:
- Remarks:
- Less than 10% hydrolysis after 5 days at 50 °C,
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other:
- Remarks:
- Less than 10% hydrolysis after 5 days at 50 °C,
- Executive summary:
Hydrolysis as a Function of pH. Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The results are as follows:
pH - rate constant - estimated half-live at 25°C
4 - not applicable - >1 year
7 - not applicable - >1 year
9 - not applicable - >1 year
Reference
Description of key information
Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
