Registration Dossier
Registration Dossier
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EC number: 701-129-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Studies investigating the acute toxicity of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salts (CAS 383178-66-3) to freshwater and marine organisms are available for all three trophic levels (fish, invertebrates, algae). Since no study is available assessing the acute toxicity of the substance to freshwater algae a read across approach using data from D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, CAS 110615-47-9) is applied to cover this endpoint. The read across is based on structural similarity between the target substance and the supporting substance. The target substance is a derivative of the supporting substance, where a carboxymethy group is added to a -OH function. All other structural elements (alkyl side chain, glycoside moiety) are identical. The additional carboxymethyl group renders the substance more hydrophilic, which usually decreases aquatic toxicity. This is confirmed by the acute ecotox data of the target substance (TS) and the supporting substance (SS): Fish: 7.1 mg/L (TS) vs 3.0 mg/L (SS); Invertebrates: 172 mg/L (TS) vs 7.0 mg/L (SS). Therefore, read across from D-Glucopyranose, oligomeric, C10-16-alkyl glycosides to D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salt is fully justified as this is considered to be a worst case approach.
Based on the EC50 values obtained for freshwater and marine fish, invertebrates and algae the test substance is considered to be acute toxic to aquatic organisms. The toxicity to marine organisms or under saltwater conditions seems to be slightly higher. Fish showed to be the most sensitive organismic group.
No studies are available investigating the long-term toxicity of the substance to freshwater organism. Therefore, test results of long-term toxicity tests with fish, Daphnia and algae performed for D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, CAS 110615-47-9) was used in a read across approach (see analogue justification above). EC10/NOEC values above 1 mg/L indicate that the test substance is very likely not harmful to aquatic organisms at chronic exposure.
Since high quality data set for freshwater and marine species are available the respective data were used to derive the PNEC of the different aquatic compartments.
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