Bis[[2,2',2''-nitrilotris[ethanolato]](1-)-N,O]bis(propan-2-olato)titanium

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

other: not specified

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Pimephales promelas

Test type:

static

Water media type:

freshwater

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 11 800 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The 96 hr LC50 for triethanolamine was 11800 mg/L tested on Pimephales promelas.

Reference 3

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data obtained from peer-reviewed secondary source.

Justification for type of information:

Data obtained from peer-reviewed secondary source.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Constant-flow procedure first cited at Alabaster and Abram (1965).

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Rasbora heteromorpha

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Key result

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

ca. 7 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 900 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 200 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

96-h LC50 (Rasbora heteromorpha) toxicity of 2-propanol is 4200 mg/L based on the nominal concentrations.

Description of key information

No studies were conducted on the target substance, Bis[[2,2',2''-nitrilotris[ethanolato]](1-)-N,O]bis(propan-2-olato)titanium. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. 

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and organic 2-propanol and 2,2',2''-Nitrilotriethanol (triethanolamine). The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply. The short-term aquatic toxicity studies of triethanolamine and 2-propanol are well-investigated are used for CSA.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

4 200 mg/L