6-nonyl-1,3,5-triazine-2,4-diamine

Endpoint summary

Description of key information

Short-term toxicity to fish:

96-h-LC50: 0.768 mg/l nominal (97. 8% a.i)

 

Short-term toxicity to aquatic invertebrates:

48h-EC50: 2.18 mg/l (nominal, 97.8 % a.i.).

 

Toxicity to aquatic algae and cyanobacteria: 

EC50: 0.031 mg/l (QSAR)

  

Toxicity to microorganisms: 

No emission to STP

Additional information

Short-term toxicity to fish:

In a 96-h acute toxicity study according to OECD guideline 203, Rainbow Trout Oncorhynchus Mykiss were exposed to Caprinoguanamine at nominal concentrations of 0, solvent control (DMF), 0.107, 0.235, 0.517, 1.14 and 2.50 mg/L under static conditions. 

The 96-h LC50 was 0.768 mg /L (nominal).  The NOEC values, based on mortality/sublethal effects, were 0.517 and 0.235 mg/L (nominal), respectively. 

No sublethal effects were observed in the control, solvent control and at the test item concentrations up to and including 0.235 mg/L. At 0.517 mg/L one fish had difficulties with maintenance of equilibrium and one fish was upside down with loss of equilibrium, showing only movement of gills as a sign of life after 24 h. After 48 h three fish had difficulties with maintenance of equilibrium. After 72 h two fish had difficulties with maintenance of equilibrium and one fish was upside down with loss of equilibrium, showing only movement of gills as a sign of life. After 96 h one fish was upside down with loss of equilibrium, showing only movement of gills as a sign of life.

 

Short-term toxicity to aquatic invertebrates:

The 48 hour acute toxicity of Caprinoguanamine to Daphnia magna Straus was studied under static conditions.  Daphnids were exposed to control, solvent control, and test chemical at nominal concentration of 0.281, 0.563, 1.13, 2.25 and 4.50 mg/L for 48 hours.  Mortality/immobilization were observed at 24 and 48 hours. 

The 48 – hour EC50 was 2.18 mg/L (nominal).  The 48 – hour NOEC based on immobilization was 1.13 mg/L (nominal). 

 

Toxicity to aquatic algae and cyanobacteria: 

ECOSAR predicted an EC50 of 0.031 mg/L in green algae for the class of aromatic triazines. This class is considered the most relevant for assessment of Caprinoguanamine.

Selection of the appropriate QSAR within ECOSAR is based on a variety of information depending on the chemical class. This includes factors like the chemical structure, chemical class, log Kow, molecular weight, physical state, water solubility, number of carbons or ethoxylates (or both), and percent amine nitrogen or number of cationic charges (or both) per 1000 molecular weight. The most important factor for selecting an appropriate QSAR is the chemical class, since the QSARs in ECOSAR are class-specific.

Furthermore effect value of 0.031 mg/L poses the worst case of all predicted values from ECOSAR classes of anilines and amino-meta anilines might relevant for assessment of Caprinoguanamine.

Toxicity to microorganisms: 

No emission to STP is expected for Caprinoguanamine.