Registration Dossier
Registration Dossier
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EC number: 233-271-0 | CAS number: 10102-43-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- other: SDS
- Title:
- Unnamed
- Year:
- 2 015
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 017
- Reference Type:
- other: online database
- Title:
- Unnamed
- Year:
- 2 017
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Classification based on practical handling experience.
NB: The compound is a gas, no regulatory in vitro test is adapted according to R.7a ECHA guidance (version 5.0, Dec 2016): OECD 430, 431, 435, 439 are not allowed for gases. - GLP compliance:
- no
- Remarks:
- not applicable, the original data date back before implementation of GLP
Test material
- Reference substance name:
- Nitrogen monoxide
- EC Number:
- 233-271-0
- EC Name:
- Nitrogen monoxide
- Cas Number:
- 10102-43-9
- Molecular formula:
- NO
- IUPAC Name:
- oxidoamine
Constituent 1
Test animals
- Species:
- other: not specified
- Strain:
- not specified
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: classification based on litterature review
- Remarks on result:
- positive indication of irritation
- Remarks:
- see below
Any other information on results incl. tables
According to the literature review, the test item is classified as follow:
- EIGA: Skin corrosion 1B, H314.
- SDS: Skin corrosion 1B. At high concentration, severe skin burning can be expected.
- ECHA: according to the notified classifications, out of 194 studies, 193 classified the test item as skin corrosion 1.
- Chiavalori: according to Order of 20 April 1994, nitrogen dioxide is classified as corrosive.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- According to the information collected in the literature, the test item can be classified as skin corrosion 1B.
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