4-methylpyridine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1972

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well conducted study similar to OECD 401 protocol. The study was done prior to implementation of GLPs.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1972

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methylpyridine

EC Number:

203-626-4

EC Name:

4-methylpyridine

Cas Number:

108-89-4

Molecular formula:

C6H7N

IUPAC Name:

4-methylpyridine

Constituent 2

Reference substance name:

g-Picoline

IUPAC Name:

g-Picoline

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

501, 631, 794, 1,000 mg/kg

No. of animals per sex per dose:

2 or 3

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

700 mg/kg bw

Based on:

test mat.

95% CL:

620 - 800

Mortality:

Rats that died prior to scheduled sacrifice did so within one to three days post dose.
501 mg/kg - 1/5
631 mg/kg - 2/5
794 mg/kg - 3/5
1,000 mg/kg - 5/5

Clinical signs:

other: Toxic signs included reduced appetite and activity (for one to three days in survivors), increasing weakness, ocular discharge containing blood and collapse

Gross pathology:

Autopsy findings in those rats that died prior to scheduled sacrifice included hemorrhagic lungs, liver discoloration and acute gastrointestinal
inflammation. The viscera of rats that survived the observation period appeared normal by macroscopic examination.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information 300 < LD50 < 2000 mg/kg. Criteria used for interpretation of results: EU

Conclusions:

The oral LD50 of 3-methylpyridine in Sprague-Dawley rats was 700 mg/kg.