Registration Dossier
Registration Dossier
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EC number: 203-626-4 | CAS number: 108-89-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case reports
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Anecdotal reports of effects of exposure of methyl pyridines.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- 3-Methylpyridine: Human toxicity excerpts
- Author:
- Anonymous
- Year:
- 2 010
- Bibliographic source:
- Hazardous Substances Data Base(HSDB), ToxNet, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rYtOpf:1
Materials and methods
- Study type:
- other: case reports
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- case reports of exposures
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-methylpyridine
- EC Number:
- 203-626-4
- EC Name:
- 4-methylpyridine
- Cas Number:
- 108-89-4
- Molecular formula:
- C6H7N
- IUPAC Name:
- 4-methylpyridine
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
4-METHYLPYRIDINE
CASRN: 108 -89 -4
For other data, click on the Table of Contents
Human Toxicity Excerpts:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCL WT
LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS. /PYRIDINE ALKYL
DERIV/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1811] **PEER
REVIEWED**
Exposures to the picolines may give rise to flushing of the face, skin
rash, an incr in heart & respiration rates, headache, giddiness, nausea
& vomiting. /Picolines/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1577] **PEER
REVIEWED**
Data indicates that 4-methylpyridine is moderately toxic when
administered orally & very toxic when given dermally & ip. Symptoms
include occasional diarrhea, weight loss, anemia, & ocular & facial
paralysis.
[Snyder, R. (ed.). Ethyl Browning's
Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II:
Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier,
1990., p. 235] **PEER REVIEWED**
4-Methylpyridine induced a dose-related increased frequency of sister
chromatid exchange in human lymphocyte cultures from three individuals.
Chromosomal aberrations induced by 4-methylpyridine included: chromatid
breaks; centromeric, intermediate & terminal chromosome breaks; terminal
& interstitial deletions; translocation; dicentric chromosomes; &
isochromosomes.
[Snyder, R. (ed.). Ethyl Browning's
Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II:
Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier,
1990., p. 235] **PEER REVIEWED**
ALKYL DERIVATIVES, PICOLINES ... CAUSE SYMPTOMS RESEMBLING THOSE
OBSERVED WITH PYRIDINE. THESE ARE LARGELY NONSPECIFIC & INCL WEAKNESS,
ATAXIA, DIARRHEA, & UNCONSCIOUSNESS. DELAYED DEATHS FOLLOWING SINGLE
DOSE ARE UNCOMMON & SURVIVORS GENERALLY GAIN WT NORMALLY. /PICOLINES/
[Clayton, G. D. and F. E. Clayton
(eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C:
Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2724]
**PEER REVIEWED**
Skin, Eye and
Respiratory Irritations:
Pyridine and its derivatives cause local irritation on
contact with the skin, mucous membranes and cornea. /Pyridine and its
derivatives/
[International Labour Office.
Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva,
Switzerland: International Labour Office, 1983., p. 1810] **PEER
REVIEWED**
A severe skin & eye irritant.
[Lewis, R.J. Sax's Dangerous Properties
of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand
Reinhold, 1996., p. 2305] **PEER REVIEWED**
Applicant's summary and conclusion
- Conclusions:
- CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCLUDE WEIGHT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS.
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