Registration Dossier
Registration Dossier
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EC number: 206-017-1 | CAS number: 288-13-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Standardized test (BASF-Test) to assess the acute dermal toxicity in rabbits.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pyrazole
- EC Number:
- 206-017-1
- EC Name:
- Pyrazole
- Cas Number:
- 288-13-1
- Molecular formula:
- C3H4N2
- IUPAC Name:
- 1H-pyrazole
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Breeder: GAUKLER, 6050 Offenbach
Mean weight for - males: 3.0 kg - females: 3.0 kg
The animals had Ssniff K, standard laboratory diet for rabbits and guinea pigs, INTERMAST GMBH, Soest and water ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- 24 h
- Doses:
- 200 and 400 mg/kg (50% in water)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Mortality:
- see table below
- Clinical signs:
- other: Apathy, diarrhoea
- Gross pathology:
- Dead animals: acute dilatation of the heart (right), degeneration; loamy liver with acute dystrophy; sandy kidneys with nephrosis
Killed animals: no substance-related pathological findings
Any other information on results incl. tables
Mortality
Dose mg/kg |
Conc. % |
Animal |
1 h |
24 h |
48 h |
7 days |
14 days |
400 200 |
50 50 |
3 m 3 f 3 m 3 f |
0/3 0/3 0/3 0/3 |
0/3 0/3 0/3 0/3 |
0/3 0/3 0/3 0/3 |
1/3 2/3 0/3 0/3 |
1/3 2/3 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 (rabbit): 400 mg/kg
- Executive summary:
A standardized test (BASF-Test) to assess the acute dermal toxicity in rabbits was performed. Three male and female rabbits per dose were exposed to the test substance under occlusive conditions for 24 hours to doses of 200 and 400 mg/kg (50% in water). The dermal LD50 in rabbits was 400 mg/kg.
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