Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 285-378-7 | CAS number: 85085-49-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha citrata, Labiatae.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Raw Material Monograph
- Author:
- D.L.J Opdyke
- Year:
- 1 992
- Bibliographic source:
- Food and Chemical Toxicology, 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The dermal irritation potential of the test chemcal was evaluated as a part of an acute dermal LD50 study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mentha citrata oil
- EC Number:
- 614-793-1
- Cas Number:
- 68917-15-7
- Molecular formula:
- C10H18O (Linalool) or C12H20O2 (Linalyl acetate)
- IUPAC Name:
- Mentha citrata oil
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Mentha citrata oil
- Molecular formula: C10H18O (Linalool) or C12H20O2 (Linalyl acetate)
- Molecular weight: 154.251- 196.288 g/mol
- Substance type: Organic
- Physical state: Clear liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 5g/kg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Slight to moderate erythema or edema was observed on guinea pigs skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Slight to moderate erythema or edema was observed on guinea pigs skin after 24 hours.
Hence, the test chemical can be considered to be irritating to guinea pig skin. - Executive summary:
The dermal irritation potential of the test chemical was evaluated as a part of an acute dermal LD50 study.5 g/kg of the undiluted material was applied under occlusion to guinea pig skin for 24 hours and observed for effects.
Slight to moderate erythema or edema was observed on guinea pigs skin after 24 hours.
Hence, the test chemical can be considered to be irritating to guinea pig skin.
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