Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: ASRI 3 hr NOEC ≥1000 mg/L (loading rate) (OECD 209)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
A reliable activated sludge respiration inhibition test is available with the registration substance and is selected as the key study. The study was conducted according to OECD method 209, and gives an EC50 of >1000 and NOEC of ≥1000 mg/L. The constituents of the registration substance hydrolyse rapidly (half-life <12 hours at pH 7 and 25°C) to [3-(2,3-epoxypropoxy)propyl]silanetriol, vinylsilanetriol, acetic acid/acetates and methanol.
In view of the test media preparation method/exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. It is not feasible or necessary to reinterpret this test result in terms of the silanol hydrolysis products.
Methanol does not have adverse effects on microorganisms (OECD, 2004).
Acetic acid does not have adverse effects on microorganisms (sodium acetate is frequently used as the control in biodegradation studies) (OECD 1992).
References
OECD (1992): OECD Guideline for testing of chemicals, Number 301, Ready biodegradability, adopted 17 July 1992.
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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