Registration Dossier
Registration Dossier
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EC number: 812-111-9 | CAS number: 188959-24-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Acetylxylan esterase is considered to be readily biodegradable according to OECD test guideline 301 based on read across from supporting enzyme substance Lipase.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The ready biodegradability of two different lipase batches was assessed in accordance OECD Procedure 301B and 301E, and in compliance with GLP. Both batches were more than 90% degraded within 28 days and the ten day window was fulfilled. In addition, the results with the reference substance were within acceptance criteria and no inhibitory effects have been observed. From these two studies it can be concluded that lipase is readily biodegradable.
Because all enzymes are built up of amino acids, the physical and chemical characteristics are very similar for different enzymes, and hence read-across from other enzymes should be fully applicable. In general, enzymes exhibit the same ecotoxicological properties which are confirmed by ecotoxicity studies performed in the industry.
Therefore, acetylxylan esterase is considered to be readily biodegradable as an enzyme with similar structure as Lipase (source substance).
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