Registration Dossier
Registration Dossier
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EC number: 609-306-4 | CAS number: 3689-69-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431 (Draft)
- Principles of method if other than guideline:
- EpiDerm™ Corrosivity-Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6,10,14-Trimethyl-5-Pentadecen-2-on
- EC Number:
- 609-306-4
- Cas Number:
- 3689-69-8
- Molecular formula:
- C18H34O
- IUPAC Name:
- 6,10,14-Trimethyl-5-Pentadecen-2-on
- Details on test material:
- - test substance: Tetrahydrofarnesylaceton (THFAC)
- batch-no: 01rg11
- substance-no: 01/0753-1
- purity: unknown
Constituent 1
- Specific details on test material used for the study:
- purity: ca. 95%
batch no.: 01rg11
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- Lot.-No. Kit: 2692
Date of test performance: 10.04.02
test concentration: undiluted
pH: 5
direct MTT reduction: no - Duration of treatment / exposure:
- 3 min and 1 h
- Number of replicates:
- - replicates: 2
- no killed tissue control used for calculation (generally only included if applicable)
Results and discussion
Any other information on results incl. tables
exposure: 3 min
| OD570 tissue 1 | OD570 tissue 2 | mean OD570 | viability [% of neg. contr.] | |
| negative controle | 1.947 | 1.734 | 1.841 | 100 |
| test substance | 1.669 | 1.827 | 1.748 | 95 |
| positive controle | 0.359 | 0.406 | 0.383 | 22 |
exposure: 1 h
| OD570 tissue 1 | OD570 tissue 2 | mean OD570 | viability [% of neg. contr.] | |
| negative controle | 1.627 | 1.748 | 1.687 | 100 |
| test substance | 1.367 | 1.796 | 1.582 | 94 |
| positive controle | 0.246 | 0.204 | 0.225 | 13 |
Applicant's summary and conclusion
- Interpretation of results:
- other: non corrosive
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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