Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
test substance eluted as three peaks using the HPLC method and the mean offset adjusted Log Pow for the test substance by UV ranged from unretained (< -1.02) to 4.65 (OECD 117, EU Method A.8 and OPPTS 830.7570).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.65
- at the temperature of:
- 40 °C
Additional information
GUIDELINE
The study was conducted using High Performance Liquid Chromatography (HPLC) and procedures in the U.S. EPA Product Properties Test Guidelines, OPPTS 830.7570,Partition Coefficient (n-Octanol/Water), Estimation by LiquidChromatography, OECD Guideline for the Testing of Chemicals, 117, Partition Coefficient(n-octanol/water), High Performance Liquid Chromatography (HPLC) Method, Official Journal of the European Communities No. L383 Method A.8: Partition Coefficient(3) and TSCA Title 40 of the Federal Code of Regulations, Part 796, Section 1570: Partition Coefficient (n-Octanol/Water).
METHODS
Three solutions of test material were prepared in 75% methanol (MeOH): 25% reagent water (H2O) v/v at a nominal concentration of 1.00 mg/mL. Each test substance solution was prepared from the appropriate stock solution in MeOH. Seven calibration reference standards, consisting of seven reference substances of known log Pow, were prepared in the respective mobile phase at a nominal concentration range (5.00 to 50.0 mg/L) selected to provide desired ultraviolet (UV) detector response. The calibration reference standard preparations were sequentially injected into an HPLC system followed by single injections of each test substance preparation. The calibration reference standards injection sequence was repeated following the test substance injections. The HPLC system was operated under standardised isocratic, reverse-phase operating conditions per the guideline.
RESULTS
The test substance eluted as three peaks using the HPLC method and the mean offset adjusted Log Pow for the test substance by UV ranged from unretained (< -1.02) to 4.65.
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