Registration Dossier
Registration Dossier
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EC number: 908-995-1 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no studies available in which the toxicokinetic properties of the registration substance were investigated.
Hordaphos CC MIS is a light yellow liquid, which is reaction mass of methyl dihydrogen phosphate and diisopropyl hydrogen phosphate and orthophosphoric acid and isopropyl dihydrogen phosphate and dimethyl hydrogen phosphate. The substance is miscible with water at room temperature in any ratio (see chapter 4.8). The octanol water partition coefficient (Log Pow) for Hordaphos CC MIS was calculated using EPI Suite. It can only be estimated as average of its different organic components which lay between -1.63 and 3.11 (see chapter 4.7). Due to the very high water solubility in combination with its organic components a general potential of bioaccumulation might be excluded.
Absorption
With reference to the considerable water solubility in water the absorption of the registration substance is considered to be readily dissolved into the gastrointestinal tract (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, Table R.7.12-1, p. 152). However, if amounts of the substance are dissolved in aqueous solutions it will dissociate into its ionic compounds (hydrolysis of esters). Ionisation does not contribute to a readily diffusion across biological membranes (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 150). Based on these properties, absorption of Hordaphos CC MIS cannot be excluded. However, no severe systemic effects were observed in the course of several oral toxicity studies in rats (acute oral toxicity study: LD50estimated to be > 2,000 mg/kg bw; reproduction toxicity screening: NOAEL 1000 mg/kg bw/d, 28 day oral toxicity: NOAEL 1000 mg/kg bw/d).
Distribution
The registration substance is water soluble. Therefore, it will diffuse though aqueous channels and pores. However, “the rate at which very hydrophilic molecules diffuse across membranes could limit their distribution” (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 159-160).
Metabolism
Taking into account the water solubility an uptake of amounts of this substance cannot be excluded. Studies on genotoxicity performed with the registration substance (Ames-Test; chromosome aberration test and HPRT test) were negative, i.e. there is no indication of a reactivity of the substance under the test conditions. With reference to its chemical composition and structure metabolism might lead to the hydrolysis of the ester binding. This conclusion is supported by the water solubility.
Excretion
With reference to the solubility the urinary excretion might be considered as the most favorable excretion route (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 161).
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
