Registration Dossier
Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Chlorobenzene is readily absorbed by mouth and by inhalation, both in animals and in humans. Studies in human volunteers showed an absorption equal to 31% and 41% of the dose administered, respectively, by mouth and by inhalation. Studies in rats showed an 18-22% absorption of the oral dose. Once absorbed, Chlorobenzene is distributed inside the body via blood and, being a lipophilic substance, accumulates mainly in fatty tissues. Finally, Chlorobenzene is eliminated in part unchanged, through the expired air, and partly after biotransformation through the urine and, to a lesser extent, the faeces. Inhalation studies in rats have shown that the amount of substance excreted via the urine in an unchanged form increases to concentrations above 400 ppm; the metabolism is probably saturated above this concentration. The metabolites of chlorobenzens are epoxides (chlorobenzene-3,4-epoxide and chlorobenzene-2,3-epoxide), with the potential to covalently bind to nucleic acids. They are formed in the liver, lungs, kidneys, and adrenal cortex, and are subsequently transformed into mercapturic acid derivatives or into chlorocatechols. At least 10 chlorobenzene metabolites (in particular 4-chlorophenyl-mercapturic acid, 4-chlorocatechol and 4-chlorophenol) can be found in the urine of humans, monkeys, rats, mice, rabbits and dogs.
Key value for chemical safety assessment
Additional information
Bibliographic source:
GESTIS substance database: Chlorobenzene.
Australian Government. Department of Health. National Industrial Chemicals Notification and Assessment Scheme (NICNAS). HUMAN HEALTH TIER II ASSESSMENT FOR Benzene, chloro-.
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