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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
BASF test, study was performed before the implementation of OECD Guidelines.
GLP compliance:
no
Remarks:
test predated GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methoxyacetic acid
EC Number:
210-894-6
EC Name:
Methoxyacetic acid
Cas Number:
625-45-6
Molecular formula:
C3H6O3
IUPAC Name:
2-methoxyacetic acid
Constituent 2
Reference substance name:
2-methoxyacetic acid
IUPAC Name:
2-methoxyacetic acid
Details on test material:
Name of test material:
Methoxyacetic acid

Impurities (identity and concentrations):
appr. 0.2 % formic acid
max. 0.5 % water
max. 0.1 % formaldehyde
< 0.1 % glycolic acid
< 0.1 % oxalic acid
< 0.5 % varied ester
< 0.001 % N

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
Concentration in vehicle (%): 0.5, 2.0, 7.0, 20.0
Application volume per dose: 10 mL/kg
Doses:
50, 200, 700, 2000 mg/kg bw
No. of animals per sex per dose:
5 per sex and dose
Control animals:
no
Details on study design:
Observation period 14 days
Statistics:
On the basis of the observed lethality, the LD50 value was determined.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 50 - < 200
Remarks on result:
other: Level of significance: 1 %

Any other information on results incl. tables

Mortality (10 animals, 5 males and 5 females):

50 mg/kg bw: 0/10

200 mg/kg bw: 10/10 (within 7 days)

700 mg/kg bw: 10/10 (within 1 day)

2000 mg/kg bw: 10/10 (within 1 h)

Clinical signs: Dyspnoea, apathy, abnormal position, reeling, atonia, tonic spasms, ruffled fur, cyanosis, paresis.

Dissection findings: No treatment-related findings were found in animals died during the study or sacrificed at the end of the observation period.

Applicant's summary and conclusion

Executive summary:

The following LD50 value has been reported after single intraperitoneal administration: Mouse, i. p. between 50 and 200 mg/kg bw. During the 14-day observation period dyspnoea and apathy were noticed in animals of all dose groups. Gross pathology revealed no treatment-related findings in all animals.