Registration Dossier
Registration Dossier
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EC number: 210-894-6 | CAS number: 625-45-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1981
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Inhalation risk test in accordance to Smyth et al. (1962). Study was performed prior to the implementation of GLP and OECD Guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- GLP compliance:
- no
- Remarks:
- test predated GLP
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- Name of test material:
Methoxyacetic acid
Impurities (identity and concentrations):
appr. 0.2 % formic acid
max. 0.5 % water
max. 0.1 % formaldehyde
< 0.1 % glycolic acid
< 0.1 % oxalic acid
< 0.5 % varied ester
< 0.001 % N
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Vapor-ladened air: 200 L air/h passing a product layer (5 cm) to create a vapor-air mixture.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 7 h
- Concentrations:
- Concentrated vapor inhalation (at 20 °C)
- No. of animals per sex per dose:
- 12
- Control animals:
- no
- Details on study design:
- Duration of observation period: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: mortality
- Exp. duration:
- 7 h
- Remarks on result:
- other: No animal died during/after incubation
- Mortality:
- All animals survived.
- Clinical signs:
- other: Closing of the eyes, snout-wiping, rhinitis
- Gross pathology:
- Organs without findings - no macroscopic effects.
Applicant's summary and conclusion
- Executive summary:
- The inhalation toxicity of methoxyacetic acid was studied in a inhalation risk test (BASF, 1981). This involved passing 200 I air/hour through a 5 cm deep layer of methoxyacetic acid at 20 °C. Twelve rats were exposed to this mixture for 7 hours. Observed symptoms of toxicity included closing of the eyes, snout- wiping and rhinitis. No deaths occurred either during exposure or during the 14 -day observation period. Autopsy revealed no macroscopic findings.
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