Registration Dossier
Registration Dossier
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EC number: 257-779-7 | CAS number: 52239-04-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: BASF internal guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- BASF method
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl N-ethyl-N-[4-[(5-nitro-2,1-benzisothiazol-3-yl)azo]phenyl]-β-alaninate
- EC Number:
- 257-779-7
- EC Name:
- Methyl N-ethyl-N-[4-[(5-nitro-2,1-benzisothiazol-3-yl)azo]phenyl]-β-alaninate
- Cas Number:
- 52239-04-0
- Molecular formula:
- C19H19N5O4S
- IUPAC Name:
- methyl N-ethyl-N-[4-[(5-nitro-2,1-benzisothiazol-3-yl)azo]phenyl]-β-alaninate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Amount / concentration applied:
- Concentration: 50% aqueous suspension
- Duration of treatment / exposure:
- 20 hours
- Observation period:
- 24 hours, 8 days
- Number of animals:
- no data
- Details on study design:
- TEST SITE
- Area of exposure: back
SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked
N - necrosis
Sch - scabbing
Na - scar
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8d
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Back:
- 24 hours: mild erythema, reversible within 8 d - Other effects:
- blue and brown remainder of test item visible on days 1 and 8
Any other information on results incl. tables
Parameters evaluated:
reddening, edema, scabbing, necrosis, scarification
Descriptors:
questionable, minimal, moderate, marked, without effect
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Slight erythema occured in within the first 24 h after a 20 h treatment on rabbit skin. No signs of skin irritation were observed after 8 d.
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