2-hexyloxyethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1987

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was not conducted in accordance with GLP but sufficient data is available for the interpretation of study results.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

not applicable

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-hexyloxyethanol

EC Number:

203-951-1

EC Name:

2-hexyloxyethanol

Cas Number:

112-25-4

Molecular formula:

C6H13OCH2CH2OH

IUPAC Name:

2-hexyloxyethanol

Details on test material:

- Name of test material (as cited in study report): Hexyl CELLOSOLVE (Ethylene glycol monohexyl ether)
- Physical state: Clear, non-viscous liquid
- Lot/batch No.: S074565

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not specified in the report

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Sealed 120 liter inhalation chamber
- Exposure chamber volume: 120 liter
- Source and rate of air: 2.5 lit/minute

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Remarks on duration:

none

Concentrations:

Substantially saturated vapor, single exposure to rats: Static conditions at 26°C

No. of animals per sex per dose:

5/sex/exposure

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observation and weekly body weights
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology

Statistics:

Means and standard deviations of animal body weights were calculated for descriptive purposes.

Results and discussion

Preliminary study:

none

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 131.58 ppm

Exp. duration:

6 h

Remarks on result:

other: substantially saturated vapor concentration (calculated)

Mortality:

A single static inhalation exposure to substantially saturated vapor produced no deaths.

Clinical signs:

other: A single static inhalation exposure to substantially saturated vapor produced no signs of inhalation toxicity.

Body weight:

Body weight gains were observed in rats at 7 and 14 days post -exposure.

Gross pathology:

No gross pathologic lesions were found in any of the animals.

Other findings:

None

Any other information on results incl. tables

none

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

A single static inhalation exposure to substantially saturated vapor (equivalent to 131.58 ppm - calculated) produced no deaths or other signs of inhalation toxicity.

Executive summary:

Ethylene glycol mono hexyl ether was evaluated for acute inhalation test in rats. Sprague-Dawley albino rats, weighing between 200 and 300 g, were exposed to substantially saturated vapor for 6 hours. The vapor was produced by enclosing the test material in a sealed 120-liter animal chamber for approximately 18 hours (static conditions) or by passing air (at 2.5 liters/min) through the sample and then through a 9-liter animal chamber (dynamic conditions). Oxygen was added, as needed, for static exposures to maintain chamber oxygen content of approximately 20%. If deaths occur, exposure times are varied to determine an LT50. Five males and 5 females are included for each exposure period.

 

Exposure to a statically-generated, substantially saturated vapor produced no deaths of 5 male or 5 female rats during or following the 6-hour test. There were no signs of toxicity or remarkable gross pathologic lesions observed.

 

A single static inhalation exposure to substantially saturated vapor (equivalent to 131.58 ppm - calculated) produced no deaths or other signs of inhalation toxicity.