Registration Dossier
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EC number: 806-984-5 | CAS number: 1392411-89-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- > 38.1 - < 183.5 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 500 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- ca. 6 - ca. 7
- Conclusions:
- Under the study conditions, water solubility of the substance was estimated to be 31.8 – 183.5 mg/L at 20.0 ± 0.5°C, corresponding to 18.2 - 31.8% of the nominal concentration.
- Executive summary:
A study was conducted to determine the solubility of the substance according to OECD 105 and EU Method A.6. The solubility of the test substance in water was determined by measurement of DOC concentration (dissolved organic carbon) in the filtered test solutions using a TOC analyser. As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water could be stated. Under the study conditions, water solubility of the substance was estimated to be 31.8– 183.5 mg/L at 20.0 ± 0.5°C, corresponding to 18.2 - 31.8% of the nominal concentration (Johannes, 2016).
Reference
The measurements from the flasks 1A-C (Days 5-7) (mean value) and 2-6 were included in the calculation of the solubility of the test substance in water.
Table 1: Measurements used for Calculation of Solubility:
| Flask | Measured Conc. Test Sub. [mg/L] |
Nominal Conc. Test Sub.[mg/L] |
Dissolved Part [%] |
pH value |
| 2 | 17.8 | 100 | 31.78 | 6.41 |
| 3 | 45.9 | 302 | 27.15 | 6.49 |
| Mean 1A-C | 67.3 | 503 | 23.90 | 6 -7 |
| 4 | 75.6 | 600 | 22.51 | 6.40 |
| 5 | 90.4 | 800 | 20.19 | 6.60 |
| 6 | 102.7 | 1009 | 18.18 | 6.63 |
As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. Therefore, the water solubility for the test substance lays in the range: 31.8 – 183.5 mg/L at 20.0 ± 0.5°C for the following nominal concentration range of the test substance in water: 100 – 1009 mg/L. Therefore, 18.2 – 31.8% of the nominal concentration of the test substance was dissolved. As dissolved carbon was measured as sum parameter for dissolved test substance, this study could not distinguish between water solubility and hydrolysis of the test substance.
Description of key information
The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Johannes, 2016).
Key value for chemical safety assessment
- Water solubility:
- 183.5 mg/L
- at the temperature of:
- 20 °C
Additional information
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