Registration Dossier
Registration Dossier
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EC number: 815-521-6 | CAS number: 72691-24-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: not according to current protocols, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- according to Smyth, H.F. et al.: Am. Ind. Hyg. Assoc. J. 23, 95-107 (1962)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- (R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
- EC Number:
- 208-205-9
- EC Name:
- (R*,R*)-α,4-dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
- Cas Number:
- 515-69-5
- Molecular formula:
- C15H26O
- IUPAC Name:
- 6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
- Test material form:
- other: liquid
- Details on test material:
- Name of the test substance used in the study report: (+-)-alpha-Bisabolol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Inhalation of an atmosphere enriched with volatile constituents at 20°C. For enrichment, 200 l air/h was passed through a layer of about 5 cm of the test substance. - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- Test substance concentration has been determined by differential weighing of the test substance before and after exposure.
- Duration of exposure:
- 7 h
- Concentrations:
- 0.14 mg/l
- No. of animals per sex per dose:
- 12
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: end of exposure d1, d3, d14
Results and discussion
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- Sacrificed animals: nothing abnormal found in organs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
