Registration Dossier
Registration Dossier
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EC number: 275-279-7 | CAS number: 71230-67-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Screening-Level Hazard Characterization Chemical Category, Stilbene Fluorescent Brighteners
- Author:
- SIDS INITIAL ASSESSMENT PROFILE
- Year:
- 2 010
- Bibliographic source:
- U.S. Environmental Protection Agency, Hazard Characterization Document, 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of Blankophor BA in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- EC Number:
- 224-073-5
- EC Name:
- Disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- Cas Number:
- 4193-55-9
- Molecular formula:
- C40H44N12O10S2.2Na
- IUPAC Name:
- disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- Test material form:
- solid
- Details on test material:
- - Name of the test material: disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
Common Name: Blankophor BA
- Molecular Formula: C40H44N12O10S2.2Na
- Molecular Weight: 960.9578 g/mol
- Substance type: Organic
- Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
Common Name: Blankophor BA
- Molecular Formula: C40H44N12O10S2.2Na
- Molecular Weight: 960.9578 g/mol
- Substance type: Organic
- Physical State: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact or scarified skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- C.I. Fluorescent Brightener 28, disodium salt in water at 50%
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14-day
- Number of animals:
- 6/group
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hrs, 14days
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of skin irritation were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate (CAS No: 4193-55-9) was not irritating to rabbit skin after 7 days of observation.
- Executive summary:
A dermal irritation study was performed to assess the irritation potential of disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate (Blankophor BA) (CAS No: 4193-55-9) in rabbits.
Two New Zealand White rabbits were exposed to 500 mg of Disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate, free acid as a dry powder applied to the inner surface the ears and covered with adhesive bandages for 24 hours. The ears were rinsed following exposure and the rabbits were observed for 7 days. No signs of skin irritation were observed.
Hence, disodium 4,4'-bis[6-anilino-[4-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate (CAS No: 4193-55-9) can be considered not irritating to rabbit skin.
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