Registration Dossier
Registration Dossier
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EC number: 218-817-8 | CAS number: 2243-62-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Migrated from Short description of key information:
406 Male guinea pigs were tested with the Maximisation test (MAGNUSSON and KLINGMAN) according to OECD guideline 406. The test was executed with following concentrations of the test substance: Intradermal Induction: 2,5% Topical Induction: 50% 1. Provokation: 50% 2. Provokation: 5% and 25 % The test substance was formulated with Cremophor EL (2% v/v) in sterile, physiological NaCl-solution. After the 1. provocation in 9 of 20 animals an obvious skin sensitization was observed with 50% test substance-formulation. After the 2. provocation with the 25% test substance-formulation in 10 animals and with the 5% test substance-formulation in 4 animals a skin sensitization was observed. The test substance was found to be sensitizing to the skin (Diesing 1989). No respiratory sensitization study is available.
Justification for classification or non-classification
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