Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 279-213-8 | CAS number: 79665-26-2
Endpoint summary
Administrative data
Description of key information
The substane is not a skin or an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a skin irritation study, 0.5 g of test substance (50% in propylene glycol/saline) was administered to the clipped skin of 3 male and 3 female New Zealand White rabbits. The test item was kept under occlusive conditions for 24 hours. Erythema and eschar formation and oedema formation were scored after 24, 48, and 72 hours, and after 4 and 7 days. No edema was observed. Due to intensive staining by the test compound erythema was not assessable, but erythema was assumed to be equal to edema based on the correlation existing (Marzulli and Maibach, Foi. Cosm. Tox. 13, 355, 1975). Therefore, under the conditions of this experiment, the test substance was found to cause no irritation when applied to rabbit skin.
In an eye irritation study, 0.1 g of test substance was administered to the eyes of 3 male and 3 female New Zealand White rabbits. The other eye served as an untreated control. In 3 out of 6 animals, the eyes were washed after 30 seconds of exposure. Observations were made on day 1, 2, 3, 4 and 7 after application. The substance was found to cause no irritation (washed or non-washed) when applied to the rabbit eye mucosa.
Justification for classification or non-classification
Based on the available information the test substance does not need to be classified for skin and eye irritation in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
