Registration Dossier
Registration Dossier
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EC number: 635-476-4 | CAS number: 88349-88-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Cloquintocet acid was not mutagenic when tested in bacterial cells and mammalian cells in vitro.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
Investigations of genetic toxicity in vivo are not required as in vitro studies all gave negative results.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The potential of cloquintocet acid to induce reverse mutations in Salmonella typhimurium (Tester strains: TA1537, TA1535, TA98, TA100 and TA102) was evaluated in the bacterial reverse mutation test according to OECD 471 (Nagane, 2013a). Negative results were obtained in the presence and in the absence of metabolic activation (S9 mix).
A mammalian chromosome aberration test (Nagane, 2013b) was carried out according to OECD 473 (1997) in human peripheral blood lymphocytes cultured in vitro. Cloquintocet acid did not show the potential to induce chromosomal aberrations in the absence and in the presence of metabolic activation (S9 mix).
An in vitro mammalian cell gene mutation assay (Nagane, 2013c) in Chinese Hamster Ovary cells [hgprt locus] was carried out according to OECD 476 (1997). No clastogenic potential was observed in the absence and in the presence of metabolic activation (S9 mix).
Justification for classification or non-classification
Cloquintocet acid is not mutagenic in bacterial cells or in mammalian cells in vitro. The substance does not meet the criteria for classification for genetic toxicity according to the CLP Regulation No.1272/2008.
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