Registration Dossier
Registration Dossier
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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- C9-C12 Mixed aliphatics and aromatics (8052-41-3) Boiling Point (C) 160-199
(Stoddard solvent; 14.5% aromatics)
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritant / corrosive response data:
- No or only very slight irritation occurred after the application of 0.1 ml of Stoddard solvent to the eyes of six rabbits. One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The eyes of six rabbits were treated with the test substance and observed for 7 days. Results indicate that the substance was not irritating .
One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
Result: not irritating at 0.1 mL. - Executive summary:
No or only very slight irritation occurred after the application of 0.1 ml of Stoddard solvent to the eyes of six rabbits. One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
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