Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride

Short-term toxicity to fish

Description of key information

In experimental study the median lethal concentration LC50 value for Short term toxicity to fishLepomis macrochirus(Bluegill)based on mortality effect for 96 hrs. exposure period was determined to be 0.51 mg/l (Dose range-0.38 to 0.69 mg/l) freshwater and static condition.

Based on the value the Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (27668-52-6) was considered to be hazardous to fish and can be classified in aquatic chronic 1 and acute 1 category as per the CLP regulation.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

0.51 mg/L

Additional information

Experimental studies and Predicted model data results of short term toxicity to fish for the target chemical Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (CAS No. 27668-52-6) with respective read across were reviewed to summarize the following information:

 

In key study from ECOTOX database; 2017 the median lethal concentration LC50 value for Short term toxicity to fish Lepomis macrochirus(Bluegill)based on mortality effect for 96 hrs. exposure period was determined to be 0.51 mg/l (Dose range-0.38 to 0.69 mg/l) freshwater and static condition. Based on the value the Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (27668-52-6) was considered to be hazardous to fish and can be classified in aquatic chronic 1 and acute 1 category.    

Another experimental result from DUPONT CHEM CO.LTD; (1992) indicate that the median tolerance limits (LT50) of test substance Dow Corning 5700 (CAS no.27668-52-6) for fish species Rainbow Trout and Bluegills were determined to be 0.56 mg/l and 0.51mg/l on the basis of behavioral effect. Based on the median tolerance limits (LT50) it is concluded that the test substance Dow Corning 5700 (Cas no.27668-52-6) was toxic to fish.

Also, the predicted data (ECOSAR v1.1 model, 2017) for target compound Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride indicate the lethal concentration (LC50) was estimated to be 1.024 mg/l on the basis of mortality effect.

 

Experimental study (J-check database;Study cited in Ministry of the Environment 2005) for read across cetrimonium bromide (Cas no. 57-09-0) indicate Short term toxicity test to fish was performed on Oryzias latipes for 96 hrs according to the OECD Guideline 203 (Fish, Acute Toxicity Test). Nominal concentrations of control, 0.100, 0.150, 0.220, 0.330, 0.500 mg/L, geometric ratio: 1.5 were used. Test conditions as semi static test type in freshwater. 10 fish per vessels and 1 replicates were used at test temperature 24 +/- 1 degree C. At the end of the experiment, the LC50 value for Hexadecyltrimethylammonium bromide (57-09-0) of short term fish was determined to be 0.278 mg/l on the basis of mortality effect with 95 % CL: 0.227 - 0.356 mg/L.This lethal concentration suggest that the test substance was hazardous to fish and thus classified in aquatic chronic 1 category as per the CLP criteria.

Thus, based on above short summaries for target chemical and read across chemical, it can be concluded that the target chemical Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (CAS No. 27668-52-6) was considered to be hazardous to fish and can be classified in aquatic chronic 1 and acute 1 category as per the CLP guideline for aquatic environment.