Registration Dossier
Registration Dossier
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EC number: 205-089-1 | CAS number: 133-08-4
Endpoint summary
Administrative data
Description of key information
There is no data available for diethyl butylmalonate (CAS # 133 -08 -4). For C&L purposes, the following data available for structurally similar substances cited in the 2006 OECD SIDS “malonic acid diesters” (UNEP Publications, Final 10/2006) is suitable for read across:
Dimethylmalonate, CAS # 108-59-8
Skin: not irritating
Eye: irritating
Diethylmalonate, CAS # 105-53-3
Skin: not irritating
Eye: irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no data available for diethyl butylmalonate (CAS # 133 -08 -4). For C&L purposes, the following data available for structurally similar substances cited in the 2006 OECD SIDS “malonic acid diesters” (UNEP Publications, Final 10/2006) is suitable for read across:
Skin:
Dimethylmalonate, CAS # 108-59-8
DMM was not irritating to rabbit skin in a study according to OECD TG 404 and GLP with 4 hours
exposure under semni occlusive conditions. Slight erythema was only observed 30 to 60 minutes
after the removal of the patch (OECD SIDS, 2006).
Diethylmalonate, CAS # 105-53-3
No guideline study is available for DEM, but it was reported t0 be slightly irritating to rabbit skin
after 24 h occlusive exposure (Moreno, 1975 cited in OECD SIDS, 2006).
Eye
Dimethylmalonate, CAS # 108-59-8
When undiluted DMM was administered to rabbit eyes (0.1 ml) without rinsing, slight 10 moderate
eye irritation was observed including conjunctival redness, chemosis, iriditis and slight corneal
opacity. All effects were reversible within 8 days. The study was performed according to OECD TG
405 and GLP (OECD SIDS, 2006).
Diethylmalonate, CAS # 105-53-3
For DEM a comparable study according to FIFRA, F 81-4 and GLP
showed comparable slight to moderate irritating effects after administration of 0.1 ml of the
undiluted test substance to rabbit eyes (OECD SIDS, 2006).
Justification for classification or non-classification
Based on the available data for read across substances Dimethylmalonate, CAS # 108-59-8 and Diethylmalonate, CAS # 105 -53 -3, Diethyl butylmalonate (CAS # 133 -08 -4) would require classification for eye irritation (Cat. 2 according to CLP) but not for skin irritation (not irritating to the skin).
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