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EC number: 205-089-1 | CAS number: 133-08-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
According to several QSAR estimations the compound is considered as acutely toxic to fish. The LC50 is estimated to be between 1 and 10 mg/L.
Key value for chemical safety assessment
Additional information
The fish toxicity was calculated with three
Toxicity classification models implemented in the Vega v1.1.0 platform
and with EPI Suite ECOSAR program v.1.11. Based on the results of the
EPI Suite calculation the LC50 of the test substance is between 10.037
mg/L (ECOSAR class calculation for Esters) and 34.913 mg/L(Neutral
Organic SAR "Baseline Toxicity"). With the short-term
toxicity-calculation using the Fish Acute (LC50) Toxicity model
(KNN/Read-Across) v1.0.0 implemented in the VEGA platform v1.1.0 an LC50
of 8.28 mg/L was observed. The fathead minnow LC50 96h (EPA) model
v1.0.7 resulted in an LC50 of 7.5 mg/L. The short-term
toxicity-calculation using the Fish Acute (LC50) Toxicity classification
(SarPy) v1.0.2 showed a LC50 in the range of 1 -1 0 mg/L for the test
item. In summary, the LC50 for fish is estimated to be between 1 and 10 mg/L.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that
information on intrinsic properties of substances may be generated by
means other than tests, provided that the conditions set out in Annex XI
(of the same Regulation) are met. Furthermore according to Article 25 of
the same Regulation testing on vertebrate animals shall be undertaken
only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can
be used if (1) the scientific validity of the (Q)SAR model has been
established, (2) the substance falls within the applicability domain of
the (Q)SAR model, (3) the results are adequate for the purpose of
classification and labeling and/or risk assessment and (4) adequate and
reliable documentation of the applied method is provided.
For the assessment of diethyl butylmalonate (Q)SAR results were used for
short-term toxicity to fish. The criteria listed in Annex XI of
Regulation (EC) No 1907/2006 are considered to be adequately fulfilled
and therefore the endpoint(s) sufficiently covered and suitable for risk
assessment.
Therefore, further experimental studies on diethyl butylmalonate are not
provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
