Registration Dossier
Registration Dossier
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EC number: 203-909-2 | CAS number: 111-80-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Version / remarks:
- A standard local lymph node assay (LLNA) protocol, as described previously, was used.
- Principles of method if other than guideline:
- A standard LLNA protocol was used.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Methyl non-2-ynoate
- EC Number:
- 203-909-2
- EC Name:
- Methyl non-2-ynoate
- Cas Number:
- 111-80-8
- Molecular formula:
- C10H16O2
- IUPAC Name:
- methyl non-2-ynoate
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- Animals were housed under standard conditions and all procedures were approved by the UK Home Office and carried out in compliance with the Animals (Scientific Procedures) Act 1986 under a Home Office granted Project License.
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- 4
Study design: in vivo (LLNA)
- Vehicle:
- other: Ethanol
- Concentration:
- 80%
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 10.4
- Test group / Remarks:
- 5%
- Parameter:
- SI
- Value:
- 17.7
- Test group / Remarks:
- 10%
- Parameter:
- SI
- Value:
- 24.4
- Test group / Remarks:
- 20%
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
- Executive summary:
According to the result in this publication, and with reference to the following studies, Methyl Octine Carbonate is considered to be a Skin Sensitiser.
ApiAM, FordRA. The use of guinea pig and human sensitization testing to determine the potential for allergic contact sensitization of methyl 2-nonynoate. J Derm Cli Eval Soc 1992: 3: 57
English J S C, Rycroft R J G. Allergic contact dermatitis from methyl heptine and methyl octine carbonates. Contact Dermatitis 1988: 18: 174–175.
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