Registration Dossier
Registration Dossier
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EC number: 203-909-2 | CAS number: 111-80-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Methyl Octine Carbonate was tested in conformity with protocol #RE (7/23/79) supplied by International Flavors and Fragrances.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl non-2-ynoate
- EC Number:
- 203-909-2
- EC Name:
- Methyl non-2-ynoate
- Cas Number:
- 111-80-8
- Molecular formula:
- C10H16O2
- IUPAC Name:
- methyl non-2-ynoate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Six health young adult albino New Zealand type rabbits with body weights in the range of 2.0 to 3.5kg at the preliminary eye examination were used.
The criteria used for housing and maintenance were those specified in the 'Guide for the Care and Use of Laboratory Animals'. [DHEW Publication No. (NIH) 78-23, Revised 1978]
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1ml
- Observation period (in vivo):
- Both eyes were scored according to the Method of Draize at 24, 48 and 72 hours and at 4 and 7 days after dosing. In addition at 24 hours and 7 days, both eyes were examined with fluorescein stain under a UV light.
- Number of animals or in vitro replicates:
- 6 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The Primary Ocular Irritation Scores were 1.0 at 24 hours and 0 and 48 and 72 hours and 4 and 7 days. Therefore Methyl Octine Carbonate was classified as non-irritating.
After 7 days, no animal had a positive score.
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