Registration Dossier
Registration Dossier
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EC number: 211-016-4 | CAS number: 627-89-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance of Isopentyl oleate (CAS 627-89-4) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substances Isopropyl oleate (CAS 112-11-8) and Isobutyl oleate (CAS 84988-79-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The toxicity of the source substance Isopropyl oleate (CAS 112-11-8) to aquatic invertebrates was tested according to a Guideline issued by Ministry of Agriculture, Fisheries and Food, United Kingdom, AEP2, 1984 (Clitherow, 1991). The test was conducted with the marine test organism Crangon crangon under semi-static conditions. The animals were exposed to nominal test substance concentrations of 850, 1530, 2640, 4760 and 8500 mg/L for 96 h. Mortality was not observed. Thus, a LC50 (96 h) > 8500 mg/L was determined.
The acute toxicity of the source substance Isobutyl oleate (CAS 84988-79-4) was tested according to the Appendix of the EU-guideline 92/69/EWG (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a static system for 48 h. Three different methods were applied for the preparation of test solutions: 1) direct addition to nominal 100 mg/L without separation of undissolved test material, 2) direct addition to nominal 100 mg/L followed by a separation of undissolved test material and 3) 3 to 5 fold saturation concentration without separation of undissolved material. Immobilisation was observed in the test solutions prepared using the first method. The observed effects were probably due to physical effects caused by the large amount of undissolved test material present in the test solution. No adverse effects were observed when the test concentrations were prepared according to method 2 and 3 respectively. It can be concluded that the test substance had no toxic effects on Daphnia magna up to the limit of water solubility. An EL50 (48 h) > 100 mg/L is reported.
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