Registration Dossier
Registration Dossier
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EC number: 211-016-4 | CAS number: 627-89-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 100% in 28 days (OECD 301B); read across
Key value for chemical safety assessment
Additional information
Experimental data investigating the biodegradability of Isopentyl oleate (CAS 627-89-4) is not available. The assessment was therefore based on a study conducted with the structural analogue substances Isopentyl laurate (CAS 6309-51-9) and and Isopropyl oleate (CAS 112-11-8) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The biodegradability of Isopentyl laurate (CAS 6309-51-9) was tested according to OECD Guideline 301B (Junghans, 2008). A degradation rate of 100% based on CO2 evolution was determined after 28 days of exposure. The biodegradation of the test item reached 80% at the end of the 10-day window. A comparable result was determined in a study on the structural analogue Isopropyl oleate (CAS 112-11-8). The biodegradability was tested according to OECD Guideline 301 B (GLP; Desmares-Koopmans, 1997). Domestic sewage was used as inoculum. During the 28-day test period, biodegradation reached 100%, based on O2 consumption, and the 10-day window criterion was met.
Based on the results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that the target substance isopentyl oleate (CAS 627-89-4) is readily biodegradable according to the OECD criteria. 5.2.2
In accordance with Regulation (EC) No 1907/2006, Annex IX, column 2, 9.2.1.2 and 9.2.1.4 simulation testing on ultimate degradation in surface water and sediment is not required. Isopentyl oleate (CAS 627-89-4) considered readily biodegradable. According to the ECHA Guidance on information requirements and chemical safety assessment, Chapter R.7b a simulation test would not provide any new findings since a rapid mineralization in the environment is already assumed (ECHA, 2016).
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