Registration Dossier
Registration Dossier
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EC number: 600-891-1 | CAS number: 1089-78-7
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
There are no studies to the carcinogenicity of hydroxy-estrenon (ZK 5252) available. However, ZK 5252 has a steroid-like structure.It has to be taken into account that steroids in general can promote the growth of specific hormone depedent tissues and tumors.
ZK 5252 has a structural similarity to nandrolone (ZK 5221) and will in vivo be transformed to ZK 5221, which is classified according to German legislation (TRGS-905) for anabolic steroids as carc. 2 and is classified with category 2 according to Regulation (EC) 1272/2008 (CLP).
Based on read across to nandrolone (ZK 5221), ZK 5252 is classified with category 2 according to Regulation (EC) 1272/2008 (CLP).
Additional information
No carcinogenicity studies are available for hydroxy-estrenon (ZK 5252). However, ZK 5252 has a structural similarity to nandrolone (ZK 5221). Only the position of one double bond differs between both substances. But the isomerisation of this double bond from 5,10 -position to 4,5 -position will easily occur in vivo. Therefore, a close effect relationship between ZK 5252 and ZK 5221 has to be assumed in vivo. These information were described in an internal communication by N. Schmees to A. Klaus (3. Jun 2016).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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