Registration Dossier
Registration Dossier
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EC number: 232-190-8 | CAS number: 7789-79-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Review
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Hypophosphite: A review
- Author:
- Rhodehamel, Pierson and Leifer
- Year:
- 1 990
- Bibliographic source:
- Journal of food protection, Vol. 53(6): 513-518
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The review considers a lot of studies performed on animals by oral or intraperitoneal administration.
- GLP compliance:
- no
Test material
- Reference substance name:
- Hypophosphite
- IUPAC Name:
- Hypophosphite
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- other: pigs, rats, cows
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Orally or intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- This is a review paper. No details on testing protocol is provided.
- Duration and frequency of treatment / exposure:
- This is a review paper. No details on testing protocol is provided.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
This is a review paper. No details on testing protocol is provided.
- No. of animals per sex per dose / concentration:
- This is a review paper. No details on testing protocol is provided.
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- Hypophosphite is completely excreted through the urine in 24 h.
- Type:
- metabolism
- Results:
- Hypophosphite is excreted unchanged. No metabolism occurs.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Hypophosphite is excreted unchanged. There is no formation of metabolites.
Applicant's summary and conclusion
- Conclusions:
- Hypophosphite is completely excreted through the urine in 24 h. No metabolic modification occors.
Bioavailability of Calcium hypophosphite is very low because it probably combines with phosphate present in food and precipitates. - Executive summary:
Hypophosphites were intensively investigated in the end of last century because they were considered a possible dietary supplements to provide extra phosphorous to the organism.
When hypophosphite were given orally or intraperitoneally to pigs rats cows and eventually human volunteers, the entire amount was excreted in the urine within 24h.
As a conclusion, hypophosphite has a very low toxicological profile but it cannot be used as dietary supplement due to the very low (or nothing) bioavailability of phosphorous.
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