Registration Dossier
Registration Dossier
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EC number: 606-203-6 | CAS number: 1902-01-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 431
- Deviations:
- yes
- Remarks:
- Reporting incomplete
- GLP compliance:
- no
Test material
- Reference substance name:
- sodium (2R)-2,4-dihydroxy-3,3-dimethyl-butanoate
- Cas Number:
- 60979-68-2
- Molecular formula:
- C6 H11 Na O4
- IUPAC Name:
- sodium (2R)-2,4-dihydroxy-3,3-dimethyl-butanoate
- Details on test material:
- - Name of test material (as cited in study report): Natriumpantoat roh, ber. 100%
- Lot/batch No.: B 671 Mischprobe
Constituent 1
Test animals
- Species:
- other: Human Skin
- Strain:
- other: EpiDerm
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: Cell Viability
- Value:
- 90
- Remarks on result:
- other:
- Remarks:
- Basis: other: Percent of negative control. Time point: 3 min. (migrated information)
- Irritation / corrosion parameter:
- other: other: Cell viability
- Value:
- 14
- Remarks on result:
- other:
- Remarks:
- Basis: other: Percent of negative control. Time point: 1 hour. (migrated information)
Applicant's summary and conclusion
- Conclusions:
- Because the substance caused cell viability after 3 min and 1 h of more than 50% and less than 15%, respectively, the substance is considered corrosive to human skin.
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