Registration Dossier
Registration Dossier
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EC number: 214-353-5 | CAS number: 1122-58-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance is not mutagenic in several bacterial Ames assays. In a mouse lymphoma assay for mammalian mutagenicity, the substance was originally evaluated as negative, but was later reassessed as "inconclusive". CASE Ultra (MultiCASE Inc.) was used to model the genetic toxicity of DMAP, using the FDA genotoxicity set (mammalian mutagenicity [mouse lymphoma assay] in vitro, chromosomal aberrations in vitro, and micronucleus formation in vivo). Although some structural alerts for mutagneicity were initially detected, further analysis of the DMAP structure predicts the substance to be nonmutagenic in vitro and in vivo. A carcinogenicity study on a structural analogue, 4-aminopyridine, provides results that a related substance is not carcinogenic, thus supporting the conclusion that the DMAP is not mutagenic or genotoxic.
Justification for selection of genetic toxicity endpoint
Experimental results and (Q)SAR
Short description of key information:
The substance is not mutagenic or genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance does not meet the criteria for mutagenicity in Regulation EC No. 1272/2008.
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