Registration Dossier
Registration Dossier
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EC number: 700-421-6 | CAS number: 1215122-81-8
Endpoint summary
Administrative data
Description of key information
Additional information
There is no experimental data on acute toxicity for the registration substance N,N-dimethyl-C12-16-(even numbered)-alkyl-1-amines, lactates. The biodegradation of the registration substance is derived from the available data of dimethyl alkylamines (DMAs) with comparable length of alkyl chain (source substances).
MICROBIAL METABOLISM
Pseudomonas MA3 is capable to use dodecyldimethyl amine as sole carbon and energy source oxidizing and cleaving the substance to dodecanal, dodecanoic acid and dimethylamine. Dodecanoic acid as a fatty acid is subsequently biodegraded by beta oxidation. The C alkyl - N bond is cleaved with help of a dehydrogenase. The metabolites dodecanal and dodecanoic acid were identified using specific enzyme inhibitors to stop further metabolism. Dimethylamine was determined by GC.
Finally the intermediate metabolites will be mineralised which means that Dodecyldimethylamine is ultimately biodegraded.
BIODEGRADATION IN WATER: SCREENING TESTS
Reliable screening studies on biodegradation are available for seven read across substances. These altogether 15 studies were performed according to OECD 301 guidelines and consistently demonstrated ready biodegradability of DMA.
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