Registration Dossier
Registration Dossier
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EC number: 614-682-8 | CAS number: 68647-95-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
For the two components of fatty acids, C18 -unsatd., dimers, compds. with coco alkyl amine, i.e., the fatty acid C18 -unsatd., dimers and primary alkyl amines, data exist for absorption, metabolism, and excretion.
Fatty acids, C18 -unstad., dimers (CAS 61788-89-4)
Several studies exist, which compared absorption of monomeric and dimeric fatty acids and their oxidized forms. Nonpolar fatty acid monomers show high digestibility (94.8% on average). Oxidized fatty acid monomers from heated olive oil have an apparent average absorption of 76.7%. Nonpolar dimers have the lowest average digestibility (10.9%), while oxidized dimers and polymers have higher apparent absorbability, ranging from 22.7% to 49.6% ( Márquez-Ruiz, G. et al., The journal of the American Oil Chemists' Society, 69(9):930-934 (1992)).
In studies comparing dermal absorption depending on fatty acid chain length, absorption decreased with increasing chain length. For C16 and C18 monomers a maximum of 0.3% was detected (see REACH registration dossier for CAS 61788 -89 -4). This result fits to the high molecular weight (> 500g/mol) and the high logPow of app. 7.
Coco alkyl amine (CAS 61788 -46 -3)
No data exist on the oral absorption of primary alky amines. Due to the high log PoW value (7 -8), the substance will be taken up by micellular solubilisation into the lymphoid system, which might limit gastro-intestinal uptake. Based on the toxicity observed after oral exposure, 100% absorption is assumed as a worst case approach, even though local irritation might account for most of the effects.
In a study with a related compound, 1 -dodecyl amine, a dermal absorption of 28% to 57% (using a concentration of 5% and 0.5%, respectively) was measured. This is considered a worst case estimate, since absorption was probably increased due to skin damage.
Fatty acids, C18 -unsatd., dimers, compds. with coco alkyl amine
Based on the data above, only about 10% of the fatty acid, C18 -unsatd., dimers will be absorbed after oral exposure. But since coco alkyl amine is considered the more dangerous compound, 100% absorption was also assumed for the test substance.
The test substance is very lipophilic (log Pow >5) and has a high molecular weight of 1000g/mol. In addition, dermal absorption was already very limited for the compounds mentioned above. Because fatty acids, C18 -unsatd., dimers, compds. with coco alkyl amine is only irritant to the skin, absorption will be increased to a lesser extent as was the case for the corrosive primary alkyl amines. Based on these factors and the data provided above, 50% absorbtion is expected for the amine, while hardly any absorption will take place for the fatty acid C18 unsatd. dimers.
Due to the very low vapour pressure of 0.0001Pa, exposure via inhalation is not considered relevant.
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