O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate

Endpoint summary

Link to relevant study record(s)

Reference

Endpoint:

basic toxicokinetics

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Additional information

The following summary is taken form the JMPR evaluation of Profenofos conducted in 2007:

 

[Phenyl-¹⁴C]profenofos was rapidly absorbed and eliminated after oral administration to rats. Total radioactivity eliminated via the urine and faeces exceeded 99% of the administered dose for a single dose of 1 or 100 mg/kg bw by gavage and repeated doses of 1 mg/kg bw by gavage. Elimination was rapid, with about of 95% of the total radiolabel being excreted in the urine within the first 24 h in all treated groups. For all doses, less than 4% of the radiolabel was excreted in the faeces. The concentration of radiolabel in tissues and organs reached a maximum after 2 h and remained at similar levels until 8 h after dosing. By 72 h, the tissue concentration of radiolabel was minimal. The absorption, distribution and excretion of ¹⁴C-labelled profenofos was not sex- or dose-dependent in the range of 1 to 100 mg/kg bw and was unaffected by pre-treatment with unlabelled profenofos for 14 days. Unchanged profenofos was detected in the faeces, but the amount was very small (approximately 1–2% of the administered dose), and this was probably the proportion of the dose that was not absorbed. Four major metabolites were present in urine and no unchanged profenofos was detected. The major metabolites were the sulfate and glucuronide conjugates of 4-bromo-2-chlorophenol that were formed by hydrolysis of the aryloxy–phosphorus bond followed by conjugation with sulfate or glucuronic acid. The other two metabolites were formed by cleavage of the phosphorus– sulfur bond either by loss of the propyl group or hydrolysis. The 4-bromo-2-chloro-phenol was detected in some urine samples, but probably arose as a result of hydrolysis of the conjugates after excretion.

                                               

References:

JMPR (2007). Pesticide residues in food. Joint FAO/WHO meeting on pesticide residues. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues. Geneva, Switzerland, 18 -27 September 2007.