Registration Dossier
Registration Dossier
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EC number: 451-900-9 | CAS number: 894406-76-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to aquatic algae was assessed in a static freshwater and static saltwater study according to EU Method C.3 and OECD Guideline 201 (Alga, Growth Inhibition Test) and EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II).
In the freshwater study Scenedesmus subspicatus was exposed to an aqueous solution of the test material at mean measured concentrations of 0, 0.0191, 0.0502, 0.152, 0.353 and 0.798 mg AI/L for 72 hours, The 72-hour EbC50 was determined 0.022 mg AI/L (0.020 – 0.026 mg AI/L), the 72-hour ErC50 was determined 0.035 mg AI/L (0.029 – 0.042 mg AI/L) and the No Observed Effect Concentration (NOEC) at 72 hours 0.0152 mg AI/L.
In the saltwater study the marine diatom, Skeletonema costatum was exposed to nominal concentrations of 0, 16, 24, 37, 55 and 83 µg AI/L, corresponding to measured concentrations of 0, 14, 20, 26, 40 and 62 µg AI/L (Day 0) and 0, 4.2, 7.1, 15, 31 and 48 µg AI/L (Day 4). The 96-hour EC50 for cell density was determined to be 25 µg/L (24 – 26 µg/L), the 96-hour NOAEC was 20 μg AI/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.035 mg/L
- EC50 for marine water algae:
- 0.025 mg/L
- EC10 or NOEC for freshwater algae:
- 0.015 mg/L
- EC10 or NOEC for marine water algae:
- 0.02 mg/L
Additional information
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