Registration Dossier
Registration Dossier
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EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented, low amount of test substance used
- Principles of method if other than guideline:
- 2 New Zealand rabbits (3-4 kg) of both sex, treatment with 50 mg/animal, conjunctival sac, observation period 7 days
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0, 24 h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
- Two New Zealand rabbits (3-4 kg) of both sex, treatment with 50 mg/animal, conjunctival sac, observation period 7 days.Result: not irritating
Not irritating to the eye
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- 2 New Zealand rabbits (3-4 kg) of both sex, treatment with 500 mg/animal for 24 hours, ear, after exposure removement of test substance with water and soap
- GLP compliance:
- no
Test material
- Reference substance name:
- Iron hydroxide oxide yellow
- EC Number:
- 257-098-5
- EC Name:
- Iron hydroxide oxide yellow
- Cas Number:
- 51274-00-1
- Molecular formula:
- Fe(OH)O
- IUPAC Name:
- Iron hydroxide oxide
- Test material form:
- solid: nanoform
- Details on test material:
- FeOOH (Eisenoxidgelb 920)
- Density: 4.1 g/mL
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 7 days
- Number of animals:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0, 24 h, 2, 3, 6, and 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Not irritating to the skin
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
- Two New Zealand rabbits (3-4 kg) of both sex, treatment with 500 mg/animal for 24 hours, ear, after exposure removement of test substance with water and soap.
Result: not irritating
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