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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific principles and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Aromatic amines in occupational environment and in biological samples.
Author:
Rimatori V and Castellino N
Year:
1989
Bibliographic source:
J Univ Occup Environ Health Suppl 11: 699-705

Materials and methods

Study type:
other: biomonitoring workers
Endpoint addressed:
not applicable
Principles of method if other than guideline:
other: biomonitoring

Test material

Constituent 1
Chemical structure
Reference substance name:
N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
EC Number:
212-344-0
EC Name:
N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
Cas Number:
793-24-8
Molecular formula:
C18H24N2
IUPAC Name:
N1-(4-methylpentan-2-yl)-N4-phenylbenzene-1,4-diamine

Method

Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
measured

Results and discussion

Any other information on results incl. tables

RS-Freetext:
In the rubber industry 6PPD was detected in the urine of
6PPD exposed workers. In environmental air levels were in
the range of < 0.01 - 260 µg/mc (peak 6600) and in urine
levels were in the range of < 1 - 300 µg/g creatinine (peak
580). The samples were collected between 1982 and 1987.

Applicant's summary and conclusion