Registration Dossier
Registration Dossier
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EC number: 212-344-0 | CAS number: 793-24-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, data from summary without detailed documentation, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of Santoflex' 13 antiozonant.
- Author:
- Randall DJ and Bannister RM
- Year:
- 1 990
- Bibliographic source:
- Acute Toxicity Data 1: 67-68
Materials and methods
- Principles of method if other than guideline:
- Method: other: in vivo eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
- EC Number:
- 212-344-0
- EC Name:
- N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
- Cas Number:
- 793-24-8
- Molecular formula:
- C18H24N2
- IUPAC Name:
- N1-(4-methylpentan-2-yl)-N4-phenylbenzene-1,4-diamine
- Details on test material:
- 6PPD: purity 95.7 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- other: undiluted (warmed to 46°C)
- Controls:
- not required
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.2
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: transient slight erythema, transient discharge and discomfort
Any other information on results incl. tables
RS-Freetext:
AVERAGE SCORE:
1.2/110
immediate: slight discomfort
1 h: slight erythema, capious discharge
24 h: slight erythema, moderate discharge
48 h: slight erythema
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
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