Registration Dossier
Registration Dossier
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EC number: 202-615-1 | CAS number: 97-88-1
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published data
Data source
Reference
- Reference Type:
- publication
- Title:
- Cytotoxicity of methyl|methacrylate (MMA) and related compounds and their interaction with dipalmitoylphosphatidylcholine (DPPC)|liposomes as a model for biomembranes.
- Author:
- Fujisawa S, Atsumi T, Kadoma Y
- Year:
- 2 000
- Bibliographic source:
- Oral Diseases 6/4: 215 - 221
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not known
- Principles of method if other than guideline:
- Study to clarify the potential mechanism of action of Methyl methacrylate (MMA) and related compounds to membranes of living cells, compared with their interaction with dipalmitoylphosphatidylcholine (DPPC) liposomes as a model for biological membranes.
- GLP compliance:
- not specified
- Type of method:
- in vitro
Test material
- Reference substance name:
- Butyl methacrylate
- EC Number:
- 202-615-1
- EC Name:
- Butyl methacrylate
- Cas Number:
- 97-88-1
- Molecular formula:
- C8H14O2
- IUPAC Name:
- butyl methacrylate
Constituent 1
Administration / exposure
- Details on study design:
- For (meth) acrylates, MMA, ethyl acrylate (EA), n-butyl acrylate (BA) and n-butyl methacrylate (BMA) and for living cells, primary human gingival fibroblast (HGF), human submandibular gland adenocarcinoma cell line (HSG) and human erythrocytes were used. The physico-chemical changes in DPPC liposomes induced by (meth) acrylates were studied using differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (NMR).
Results and discussion
- Details on results:
- Cytotoxicity decreased as follows: Butyl acrylat > n-Butyl methacrylate > Ethyl acrylate > Methyl methacrylate
Applicant's summary and conclusion
- Conclusions:
- Using a valid experimental method, n-Butylmethacrylate exhibited large cytotoxicity and high Dipalmitoylphosphatidylcholine (DPPC)-interaction due to their lipophilicity compared to Ethyl acrylate or Methyl methacrylate.
- Executive summary:
Using a valid experimental method, n-Butylmethacrylate exhibited large cytotoxicity and high Dipalmitoylphosphatidylcholine (DPPC)-interaction due to their lipophilicity compared to Ethyl acrylate or Methyl methacrylate.
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