Registration Dossier
Registration Dossier
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EC number: 232-094-6 | CAS number: 7786-30-3
Carcinogenicity
Administrative data
Description of key information
The repeated dose and carcinogenicity available show no evidence of compound-related carcinogenicity.
Key value for chemical safety assessment
Justification for classification or non-classification
On the basis of the dose repeated studies, the MgCl2 was not classified for carcinogenic toxicity under the CLP regulation 1272/2008.
Additional information
MgCl2 is not classified as a mutagen category 3 and there is no evidence from the repeat dose studies that MgCl2 is able to induce hyperplasia and/or pre-neoplastic lesions. According to annex X, section 8.9.1, column 2 of REACH regulation, a carcinogenicity study is not warranted.
Kurata Y. et al, 1982 support this information in the fact that there is no evidence of compound-related carcinogenicity. In this study, groups of 50 male and 50 female B6C3F1 mice were given MgCl2, 6H20 at dose levels of 0.5 and 2% (3930 mg/kgbw/day for female and 2810 mg/kg bw/day for male) in the diet for 96 week, after which all animals received the control diet for 8 wk and were then necropsied.
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